From the Publisher: 

A new way to play UNO where each player becomes a Marvel hero with their own unique deck. But get ready, other players and unexpected Marvel villains will team-up to take you down! And when you're down to your last card, don't yell "assemble", yell UNO!

Two ways to win. Get rid of all the cards in your hand or be the last player with cards left in your Character Deck.

Character decks include Spider-Man, Scarlet Witch, or Doctor Strange.